Joshua Levitz*#, Johannes Broichhagen*, Philipp Leippe, David Konrad, Dirk Trauner#, Ehud Y. Isacoff#. Dual optical control and mechanistic insights into photswitchable group II and III metabotropic glutamate receptors. PNAS. 2017. Vol. 114. E3546-54.

# = corresponding author


Joshua Levitz, Chris Habrian, Shashank Bharill, Zhu Fu, Reza Vafabakhsh, Ehud Y. Isacoff. Mechanism of assembly and cooperativity of homomeric and heteromeric metabotropic glutamate receptors. Neuron. 2016. Vol. 92, 1-17.

Joshua Levitz*, Perrine Royal*, Yannick Comoglio, Sebastien Schaub, Daniel Clemens, Ehud Y. Isacoff, Guillaume Sandoz. Heterodimerization within the TREK channel subfamily produces a diverse family of highly regulated potassium channels. PNAS. 2016. Vol. 113, 4194-4199.

Joshua Levitz*, Andreas Reiner*, Andrei Popescu*, Ehud Y. Isacoff. A toolkit for orthogonal and in vivo optical manipulation of ionotropic glutamate receptors. Frontiers in Molecular Neuroscience. 2016. Vol. 9.

David Barber, Matthias Schonberger, Jessica Burgstaller, Joshua Levitz, Braxton Norwood, C. David Weaver, Ehud Y. Isacoff, Herwig Baier, Dirk Trauner. Optical control of GIRK channels using a light operated GIRK opener (LOGO). Chemical Science. 2016. Vol. 7, 2347-52.


Johannes Broichhagen*, Arunas Damijonaitis*, Joshua Levitz*, Kevin Sokol, Phillip Leippe, David Konrad, Ehud Y. Isacoff, Dirk Trauner. Orthogonal optical control of a class C G protein-coupled receptor using a SNAP-tethered photoswitch. ACS Central Science. 2015. Vol. 1, 383-93.

Reza Vafabakhsh*, Joshua Levitz*, Ehud Y. Isacoff. Conformational dynamics of a class C G protein-coupled receptor. Nature. 2015. Vol. 524, 497-501.

Andreas Reiner*, Joshua Levitz*, Ehud Y. Isacoff. Controlling ionotropic and metabotropic glutamate receptors with light: principles and potential. Current Opinion in Pharmacology. 2015. Vol. 20, 1-9. (Review)

Elizabeth Carroll, Shai Berlin, Joshua Levitz, Michael Kienzler, Zhe Yuan, Dorte Madsen, Delmar Larsen, Ehud Y. Isacoff. Two-photon brightness of azobenzene photoswitches designed for glutamate receptor optogenetics. PNAS. 2015. Vol. 112: E776-85.


Yannick Comoglio*, Joshua Levitz*, Michael Kienzler, Florian Lesage, Ehud Y. Isacoff, Guillaume Sandoz. Phospholipase D2 specifically regulates TREK potassium channels via direct interaction and local production of phosphatidic acid. PNAS. 2014. Vol. 111, 13547-13552. 


Andreas Reiner, Joshua Levitz, Ehud Y. Isacoff. Bringing optogenetics to the synapse. Neuron. 2013. Vol. 79, 209-10. (Review)

Guillaume Sandoz and Joshua Levitz. Optogenetic techniques for the study of native potassium channels. Frontiers in Molecular Neuroscience. 2013. Vol. 6. (Review)

Joshua Levitz, Carlos Pantoja, Benjamin Gaub, Harald Janovjak, Andreas Reiner, Adam Hoagland, David Schoppik, Brian Kane, Philipp Stawski, Alexander Schier, Dirk Trauner, Ehud Y. Isacoff. Optical control of metabotropic glutamate receptors. Nature Neuroscience. 2013. Vol. 16, 507-16.


Guillaume Sandoz, Joshua Levitz, Richard Kramer, Ehud Y. Isacoff.  Optical control of endogenous proteins with a photoswitchable conditional subunit reveals a role for TREK1 in GABAB signaling. Neuron. 2012. Vol. 74, 1005-1014.


Luke H. Chao, Margaret M. Stratton, Il-Hyung Lee, Oren Rosenberg, Joshua Levitz, Daniel J. Mandell, Tanja Kortemme, Howard Schulman, John Kuriyan. A mechanism for tunable autoinhibition in the structure of a human Ca2+/calmodulin-dependent kinase II holoenzyme. Cell. 2011. Vol. 146, 732-745.

* = Equal Contribution